:root{color-scheme:dark;--bg:#090b0d;--panel:#111518;--panel2:#181c1f;--gold:#d4b57b;--muted:#939a9d;--text:#e9e9e4;--line:#34332d;--green:#72c9a4;--red:#ef8c7e;--blue:#82b9ec;--purple:#c3a2e8}*{box-sizing:border-box}body{margin:0;background:var(--bg);color:var(--text);font:15px/1.65 -apple-system,BlinkMacSystemFont,'Segoe UI','PingFang SC','Microsoft Yahei',sans-serif}button,input,select{font:inherit}button,a,input,select{-webkit-tap-highlight-color:transparent}button{cursor:pointer;background:#1d201f;color:var(--text);border:1px solid #41433d;border-radius:8px;padding:10px 15px;min-height:44px}button:hover{border-color:var(--gold)}button:disabled{opacity:.35;cursor:default}a{color:var(--gold);text-decoration:none}a:hover{text-decoration:underline}button:focus-visible,a:focus-visible,input:focus-visible,select:focus-visible{outline:2px solid var(--gold);outline-offset:3px}header{height:88px;max-width:1536px;margin:auto;display:flex;justify-content:space-between;align-items:center;padding:0 36px;border-bottom:1px solid var(--line)}.brand{display:flex;align-items:center;gap:12px;color:var(--text);font-size:24px;letter-spacing:1px;font-weight:600;line-height:1.2}.brand b{color:var(--gold);font-weight:400}.brand small{display:block;font-size:10px;color:var(--muted);letter-spacing:3px;margin-top:7px}.brandmark{color:var(--gold);font-size:46px;font-weight:300}.headright{display:flex;align-items:center;gap:9px;color:var(--muted);font-size:10px;letter-spacing:1.5px}.live{height:5px;width:5px;border-radius:50%;background:var(--green)}.version{border:1px solid var(--line);padding:4px 8px;color:var(--gold);margin-left:20px}.layout{max-width:1536px;margin:auto;display:grid;grid-template-columns:210px minmax(0,1fr)}aside{border-right:1px solid var(--line);padding:35px 18px;min-height:calc(100vh - 88px)}aside a{display:flex;gap:12px;padding:13px 14px;color:var(--muted);font-size:13px;margin-bottom:8px;border-radius:8px}aside a.active{background:#27241c;color:var(--gold);border-left:2px solid var(--gold)}aside .label{font-size:10px;letter-spacing:2px;color:#696f72;padding:0 14px;margin:14px 0 20px}main{min-width:0;padding:34px 38px 80px}h1,h2,h3,h4{line-height:1.35}h1{font-size:32px;font-weight:600;margin:10px 0 15px}h2{font-size:22px;font-weight:500;margin:0 0 10px}h3{font-size:17px;font-weight:500;margin:0 0 10px}h4{font-size:15px;color:var(--gold);margin:16px 0 6px}p{margin:8px 0 14px}.muted,.note{color:var(--muted)}.note{font-size:12px}.eyebrow{font-size:10px;color:var(--gold);letter-spacing:2px}.hero{display:grid;grid-template-columns:1.1fr 1fr;border:1px solid #514635;border-radius:14px;overflow:hidden;background:linear-gradient(110deg,#211e17 0%,#111619 65%);min-height:310px}.hero-copy{padding:34px}.hero-copy h1{font-size:38px}.hero-copy p{max-width:410px;color:#b8b9b1}.primary{background:var(--gold);border-color:var(--gold);color:#171510;font-weight:600}.ghost{color:var(--gold);background:transparent;border-color:#5b503d}.hero-visual{position:relative;padding:22px;background:radial-gradient(ellipse,#282d29,transparent 65%);display:flex;align-items:center;justify-content:center}.hero-visual svg{width:100%;height:260px}.hero-visual text{font-family:inherit}.sectionhead{display:flex;justify-content:space-between;align-items:center;gap:12px;margin:30px 0 17px}.sectionhead h2{margin:0}.cards{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:14px}.card{display:block;color:var(--text);padding:21px;border:1px solid var(--line);border-radius:11px;background:var(--panel);text-align:left;position:relative}.card:hover{text-decoration:none;border-color:#8a7550;background:#171b1d}.card .num{font-size:10px;color:#7b735f;letter-spacing:2px}.card .symbol{font-size:28px;color:var(--gold);display:block;margin:13px 0}.card strong{font-size:17px;font-weight:500;display:block}.card p{font-size:12px;color:var(--muted);margin:7px 0 0}.card .arrow{position:absolute;right:20px;top:18px;color:var(--gold)}.stats{display:grid;grid-template-columns:repeat(3,1fr);gap:12px;margin:20px 0}.stat{border-top:1px solid var(--line);padding:18px 8px 0}.stat b{font-size:25px;font-weight:400;color:var(--gold)}.stat small{display:block;color:var(--muted);font-size:11px}.panel{padding:22px;background:var(--panel);border:1px solid var(--line);border-radius:11px;margin:16px 0}.toolbar{display:flex;flex-wrap:wrap;gap:8px;align-items:center}.toolbar .spacer{flex:1}.pill{border-radius:30px;font-size:12px;padding:7px 13px;min-height:36px;background:transparent}.active.pill{background:var(--gold);border-color:var(--gold);color:#16140f}.tag{display:inline-block;font-size:10px;letter-spacing:.3px;color:var(--gold);border:1px solid #615238;border-radius:4px;padding:2px 6px;margin:2px 3px 2px 0}.tag.red{color:var(--red);border-color:#794940}.tag.green{color:var(--green);border-color:#396d57}.tag.blue{color:var(--blue);border-color:#3b5c78}.tag.purple{color:var(--purple);border-color:#665278}.pathhead{display:flex;justify-content:space-between;gap:12px;margin:23px 0 15px}.pathhead h2{margin:3px 0 9px}.pathhead p{margin:0;font-size:13px;color:var(--muted)}.legend{display:flex;gap:12px;flex-wrap:wrap;font-size:11px;color:var(--muted);margin:10px 0}.legend b{color:var(--gold);font-weight:400}.mapframe{border:1px solid #5d503a;border-radius:12px;overflow:hidden;background:#0c1012;position:relative}.maptools{display:flex;gap:6px;padding:10px;border-bottom:1px solid var(--line);flex-wrap:wrap;align-items:center;background:#14191b}.maptools button{padding:6px 10px;min-height:34px;font-size:12px}.maptools span{font-size:10px;color:var(--muted);margin-left:auto}.mapviewport{width:100%;height:620px;overflow:hidden;position:relative;background-image:radial-gradient(#30372e 1px,transparent 1px);background-size:24px 24px}.mapviewport svg{width:100%;height:100%;touch-action:none;user-select:none;-webkit-user-select:none;display:block}.mapfooter{border-top:1px solid var(--line);font-size:11px;color:var(--muted);padding:10px 14px;display:flex;justify-content:space-between}.mapframe.expanded{position:fixed;inset:0;z-index:40;border-radius:0;display:flex;flex-direction:column}.expanded .mapviewport{height:auto;flex:1}.mapnode{width:100%;height:100%;background:#141a1d;border:1px solid #59604e;border-radius:10px;display:flex;flex-direction:column;align-items:center;justify-content:center;padding:10px;color:var(--text);cursor:pointer;font-size:14px;line-height:1.3;overflow:hidden}.mapnode img{width:100%;height:105px;object-fit:contain;pointer-events:none}.mapnode b{font-weight:500;color:#e4e5da}.mapnode small{font-size:9px;color:var(--muted);margin-top:3px}.mapnode:hover{border-color:var(--gold)}.enzlabel{width:100%;height:100%;background:#141b1d;border:1px solid #384640;color:#b7c3bc;border-radius:7px;font-size:11px;padding:5px 7px;min-height:0;line-height:1.35;display:flex;flex-direction:column;align-items:center;justify-content:center}.enzlabel.key{border-color:#9d8050;color:var(--gold);background:#272319}.enzlabel.irrev{border-right:3px solid var(--red)}.enzlabel small{font-size:9px;color:var(--green);margin-top:2px}.mapnode.simplified{background:#1b2020}.mapnode.simplified img{height:72px}.mapnode .mask{color:var(--gold);font-size:15px}.grid2{display:grid;grid-template-columns:1fr 1fr;gap:18px}.grid2 .panel{margin:0}.callout{border-left:2px solid var(--gold);background:#201e17;padding:14px 17px;font-size:13px;margin:16px 0}.callout p{margin:3px 0}.fields{display:flex;gap:13px;flex-wrap:wrap;margin-bottom:16px}.field{flex:1;min-width:140px;display:flex;flex-direction:column;gap:5px;font-size:12px;color:var(--muted)}input,select{width:100%;border:1px solid #464942;border-radius:7px;background:#0c1012;padding:11px;color:var(--text);min-height:44px}input[type=checkbox]{width:18px;min-height:18px;accent-color:var(--gold)}label.check{display:flex;align-items:center;gap:8px;font-size:13px}.search{max-width:460px}.result{background:#252219;border:1px solid #4d4531;border-radius:8px;padding:16px;margin:15px 0}.bigvalue{font-size:35px;color:var(--gold);line-height:1.4}.chart{width:100%;height:auto;background:#0c1114;border:1px solid var(--line);border-radius:8px}.tablewrap{overflow:auto}.table{width:100%;border-collapse:collapse;font-size:13px}.table th,.table td{text-align:left;border-bottom:1px solid var(--line);padding:11px 10px}.table th{color:var(--gold);font-weight:500;background:#1d211f}.table td{color:#b9c0bd}.aaGrid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px;margin-top:20px}.aa{padding:16px}.aa img{width:100%;height:145px;object-fit:contain}.aa .code{color:var(--gold);font-size:22px}.aa small{display:block;color:var(--muted);font-size:11px}.aa h3{margin:8px 0 0;font-size:15px}.aa .aameta{display:flex;justify-content:space-between;border-top:1px solid var(--line);padding-top:9px;margin-top:8px;font-size:11px;color:var(--muted)}.protein-level{display:grid;grid-template-columns:repeat(4,1fr);gap:12px}.protein-level div{padding:18px;background:#171c1f;border-radius:8px;border:1px solid var(--line)}.protein-level b{color:var(--gold)}.process{display:flex;align-items:center;justify-content:space-evenly;padding:25px 10px;gap:8px;background:#0d1214;border:1px solid var(--line);border-radius:8px}.process b{font-size:22px;font-weight:400;color:var(--gold)}.process small{font-size:10px;color:var(--muted);display:block}.codegrid{display:grid;grid-template-columns:repeat(4,1fr);gap:7px;margin-top:18px}.codongroup{border:1px solid var(--line);border-radius:6px;padding:8px;font-size:11px}.codongroup div{padding:3px;display:flex;justify-content:space-between;gap:4px}.codongroup strong{color:var(--gold)}.option{display:flex;align-items:center;width:100%;gap:10px;text-align:left;margin:9px 0;background:#151b1e}.option.chosen{border-color:var(--gold);background:#28241b}.option.correct{border-color:var(--green);color:var(--green)}.option.wrong{border-color:var(--red);color:var(--red)}.option span{color:var(--gold);border:1px solid #4d493c;border-radius:4px;width:25px;text-align:center;flex-shrink:0}.question-img{max-width:360px;width:100%;height:190px;object-fit:contain;border:1px solid var(--line);border-radius:9px}.progressbar{height:4px;background:#30362f;margin:20px 0}.progressbar div{height:100%;background:var(--gold)}details{border-bottom:1px solid var(--line);padding:14px 0}summary{cursor:pointer;color:var(--gold)}dialog{max-width:820px;width:calc(100% - 30px);max-height:90dvh;background:#111719;color:var(--text);border:1px solid #78623e;border-radius:14px;padding:0;box-shadow:0 30px 100px #0008}dialog::backdrop{background:#000b;backdrop-filter:blur(4px)}.dialogbar{display:flex;justify-content:space-between;align-items:center;position:sticky;top:0;background:#151b1d;padding:12px 20px;border-bottom:1px solid var(--line);z-index:2}.dialogbar button{padding:2px 10px;min-height:36px;background:transparent;border:0}#drawerBody{padding:24px}.reaction{display:flex;align-items:center;gap:10px;justify-content:center;flex-wrap:wrap;margin:20px 0}.molcard{flex:1;min-width:180px;text-align:center;border:1px solid var(--line);border-radius:9px;background:#0c1114;padding:10px}.molcard img{width:100%;height:160px;object-fit:contain}.molcard small{color:var(--muted);display:block;font-size:11px}.molcard b{font-size:13px;font-weight:500}.molbig{width:100%;height:300px;object-fit:contain;border:1px solid var(--line);border-radius:9px;background:#0c1114}.data-list{display:grid;grid-template-columns:120px 1fr;font-size:13px;gap:0;margin:12px 0}.data-list dt,.data-list dd{padding:10px 0;border-bottom:1px solid var(--line);margin:0}.data-list dt{color:var(--muted)}.dialog-nav{display:flex;justify-content:space-between;margin-top:20px}.empty{padding:25px;color:var(--muted);text-align:center}.footer{border-top:1px solid var(--line);padding-top:20px;margin-top:35px;font-size:11px;color:#767f80}.footer a{margin-right:13px}#toast{position:fixed;left:50%;bottom:95px;transform:translateX(-50%);background:#d4b57b;color:#121512;border-radius:7px;padding:10px 16px;z-index:100;font-size:13px;display:none;max-width:90vw}#bottom{display:none}.minirow{display:flex;align-items:center;justify-content:space-between;gap:12px}.steps-list{padding-left:22px;color:#c0c8c4}.steps-list li{margin:10px 0}.balance{font-size:13px;color:var(--green);overflow-wrap:anywhere}.error{color:var(--red)}.hidden{display:none!important}.source-link{font-size:11px;word-break:break-all}.generic{width:100%;height:105px;display:flex;align-items:center;justify-content:center}.generic svg{width:100%;height:100%}.generic text{font-family:Arial,sans-serif;fill:#dde2dc}.concept-lines{height:70px;display:flex;align-items:center;justify-content:center;color:var(--gold);font-size:25px;letter-spacing:4px}.badge-number{color:var(--gold);font-size:11px;border:1px solid #655337;border-radius:5px;padding:3px 7px}.kbd{font-family:monospace}.related{display:flex;gap:8px;flex-wrap:wrap}.related button{font-size:12px}#searchHits{display:grid;gap:8px;margin-top:10px}#searchHits a{font-size:13px;border:1px solid var(--line);padding:8px;border-radius:6px}.formula-note{font-size:11px;color:#848f91}
@media(min-width:1400px){main{padding:40px 50px 80px}}@media(max-width:1100px){.layout{grid-template-columns:175px minmax(0,1fr)}main{padding:28px 25px 80px}.hero-copy{padding:25px}.hero-copy h1{font-size:31px}.hero{grid-template-columns:1.2fr 1fr}.cards{gap:10px}.card{padding:17px}.aaGrid{grid-template-columns:repeat(2,1fr)}.protein-level{grid-template-columns:repeat(2,1fr)}}
@media(max-width:760px){header{height:74px;padding:0 18px}.brand{font-size:21px;gap:8px}.brandmark{font-size:37px}.brand small{font-size:9px;letter-spacing:2px}.headright{font-size:0;gap:0}.headright .live{display:none}.version{font-size:10px;margin:0}.layout{display:block}aside{display:none}main{padding:24px 17px 115px}h1{font-size:27px}h2{font-size:20px}.hero{grid-template-columns:1fr}.hero-copy{padding:25px 23px 8px}.hero-copy h1{font-size:31px}.hero-visual{padding:0 25px}.hero-visual svg{height:215px}.hero-copy p{font-size:13px}.cards{grid-template-columns:repeat(2,minmax(0,1fr));gap:11px}.card{padding:17px 15px;min-height:155px}.card strong{font-size:15px}.card p{font-size:11px}.card .symbol{margin:10px 0;font-size:26px}.sectionhead{margin-top:25px}.sectionhead h2{font-size:18px}.sectionhead .note{font-size:10px}.panel{padding:17px}.grid2{grid-template-columns:1fr;gap:14px}.pathhead{display:block}.pathhead .tag{margin-top:8px}.mapviewport{height:570px}.maptools{gap:5px;padding:8px}.maptools span{width:100%;margin:0}.maptools button{min-height:36px}.mapfooter{font-size:9px}.legend{gap:9px;font-size:10px}.field{min-width:125px}.aaGrid{gap:9px}.aa{padding:13px 10px}.aa img{height:125px}.aa .code{font-size:18px}.aa h3{font-size:14px}.aameta{flex-wrap:wrap;gap:4px}.codegrid{gap:4px}.codongroup{padding:4px;font-size:10px}.process b{font-size:18px}.process{padding:20px 8px}.protein-level{gap:8px}.protein-level div{padding:13px}.protein-level p{font-size:12px}.data-list{grid-template-columns:95px 1fr}.molcard{min-width:130px}.molcard img{height:120px}#drawerBody{padding:20px 16px}dialog{width:calc(100% - 16px);max-height:94dvh;border-radius:13px}#bottom{display:flex;position:fixed;bottom:0;left:0;right:0;background:#101618f5;border-top:1px solid #414130;padding:8px 6px max(10px,env(safe-area-inset-bottom));z-index:20;justify-content:space-around;backdrop-filter:blur(14px)}#bottom a{color:var(--muted);font-size:10px;padding:4px 6px;text-align:center;min-width:42px}#bottom a span{display:block;font-size:20px;line-height:1.3}#bottom a.active{color:var(--gold)}.reaction{gap:6px}.bigvalue{font-size:29px}.pathTabs{flex-wrap:nowrap;overflow:auto;padding-bottom:8px;margin-right:-17px}.pathTabs button{white-space:nowrap;flex-shrink:0}.footer{font-size:10px}.footer a{display:inline-block;margin-top:7px}}@media(max-width:350px){main{padding-left:12px;padding-right:12px}.card strong{font-size:13px}.headright{display:none}.fields{gap:8px}.field{min-width:110px}.codegrid{grid-template-columns:repeat(2,1fr)}}@media(max-height:500px) and (orientation:landscape){.mapviewport{height:330px}#bottom{padding:3px}#bottom a span{font-size:15px}dialog{max-height:98dvh}}@media(prefers-reduced-motion:no-preference){.card,button{transition:background .15s,border-color .15s}main{animation:appear .2s ease}@keyframes appear{from{opacity:.6;transform:translateY(3px)}to{opacity:1;transform:none}}}
/* Keep horizontal scrolling inside the pathway tabs, including 320 px viewports. */
@media(max-width:760px){.pathTabs{margin-right:0;scrollbar-width:thin}.maptools span{overflow-wrap:anywhere}.molbig{max-width:100%}}
@media(max-height:500px) and (orientation:landscape) and (max-width:1000px){aside{display:none}.layout{display:block}header{height:60px;padding:0 20px}.brandmark{font-size:32px}.brand{font-size:19px}main{padding:20px 22px 80px}#bottom{display:flex;position:fixed;bottom:0;left:0;right:0;justify-content:space-around;z-index:20;border-top:1px solid var(--line);background:#101618f5;padding:3px 10px}#bottom a{font-size:10px;text-align:center;color:var(--muted)}#bottom a span{display:block;font-size:16px}#bottom a.active{color:var(--gold)}}
/* Stack reaction structures on phones instead of shrinking two molecules side by side. */
@media(max-width:600px){.reaction{flex-direction:column;gap:10px}.reaction .molcard{width:100%;min-width:0;flex:auto}.reaction .molcard img{height:180px}.reaction>span{transform:rotate(90deg)}}